首页|Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

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5-Methylcytosine(5mC)is a dynamic and reversible epigenetic modification in genomic DNA of higher eukaryotes.It has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation(TET)-mediated oxidation of 5mC fol-lowed by thymine DNA glycosylase(TDG)-initiated base excision repair(BER).Recent findings also have identified an alternative pathway of DNA demethylation.In this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine(5fC)or 5-carboxylcytosine(5caC).These modified bases can undergo direct deformylation or decarboxylation,respectively.Additionally,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil(5hmU),respectively.Various DNA demethylation pathways possess critical functional implications and roles in biological processes.This Recent Advances article will focus on the studies of mechanisms and biological functions of DNA de-methylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

EpigeneticsDNADNA methylation5-MethylcytosineDemethylationMechanismsBiological functionsC-C bond cleavageMass spectrometry

Yang Feng、Sheng-Jun Chen、Bi-Feng Yuan

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Key Laboratory of Aquatic Product Processing,Ministry of Agriculture and Rural Affairs,National R&D Center for Aquatic Product Processing,South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou,Guangdong 510300,China

School of Public Health,Research Center of Public Health,Renmin Hospital of Wuhan University,Wuhan University,Wuhan,Hubei 430071,China

国家自然科学基金Guangdong Basic and Applied Basic Research FoundationCentral Publicinterest Scientific Institution Basal Research FundSouth China Sea Fisheries Research Institute,CAFSGuangzhou Basic and Applied Basic Research FoundationCentral Publicinterest Scientific Institution Basal Research Fund,CAFS

220741102022A15151105502021TS022023A04J13372023TD78

2024

10.1002/cjoc.202300576

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(6)
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