首页|Sarcocinerenoids A-J,Eight Rare Capnosane-Type and Two New Cage-Type Cembranoids with Promoting Angiogenesis Activity from the South China Sea Soft Coral Sarcophyton cinereum

Sarcocinerenoids A-J,Eight Rare Capnosane-Type and Two New Cage-Type Cembranoids with Promoting Angiogenesis Activity from the South China Sea Soft Coral Sarcophyton cinereum

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Eight rare capnosane-type cembranoids,sarcocinerenoids A-H(1-8)and two new cage-type cembranoids sarcocinerenoids I-J(9-10)were isolated from the soft coral Sarcophyton cinereum.The 5/11 bicyclic carbon skeleton is the same in Sarcocinerenoids A-H(1-8),and they collocate distinctive oxygen rings.Sarcocinerenoids I-J(9-10)with a cage-type structure have been discov-ered to have an oxygen bridge and an uncommon seven-membered ring.Extensive spectroscopic investigation,X-ray diffraction analysis,estimated ECD,and DP4+probability assessments were used to ascertain the structures of the two types of diterpenoids.Moreover,compounds 1,4 showed promoting angiogenesis activity in zebrafish assays.

Soft coralSarcophyton cinereumCapnosane-type cembranoidsAbsolute configurationsActivitiesNatural productsNMR spectroscopyLiquid chromatographyX-ray diffractionChiral resolution

Yue Mi、Yanan Yang、Xuli Tang、Xiao Han、Guoqiang Li

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Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China

College of Chemistry and Chemical Engineering,Ocean University of China,Qingdao,Shandong 266100,China

Laboratory of Marine Drugs and Biological Products,National Laboratory for Marine Science and Technology,Qingdao,Shandong 266235,China

国家自然科学基金

U2006204

2024

10.1002/cjoc.202300592

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(8)
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