首页|Synthesis of Organofluorine Compounds with Acylsilanes
Synthesis of Organofluorine Compounds with Acylsilanes
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Organofluorine compounds are central in synthetic chemistry,medicinal chemistry and material chemistry.In this review,we sum-marize the investigations on the synthesis of organofluorine compounds with acylsilanes.For the non-fluorinated acylsilanes,the in situ generation of difluoroenoxysilanes from the reactions of the acylsilanes with trifluoromethylation reagents is the major pathway,leading to the facile preparation of various a,a-difluoroketones.For the fluoroalkylacylsilanes,apart from the in situ generation of difluoroenoxysilanes through anion Brook rearrangement,radical Brook rearrangement of the photoexcited acylsilanes and the se-lective control of reactivities of the biradicals pave the way for the synthesis of a variety of organofluorine compounds.In general,most of these reactions gave racemic products,and the asymmetric synthesis of organofluorine compounds with acylsilanes is still rare,which would be a future direction of this field.
The Institute for Advanced Studies,Engineering Research Center of Organosilicon Compounds & Materials,Ministry of Education,Wuhan University,299 Bayi Road,Wuhan,Hubei 430072,China
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