首页|Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell
Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell
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The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are wide-ly found in pharmaceuticals and agrochemicals.Herein,we disclose an electrochemical dearomative spirocyclization of N-acyl sulfon-amides in a continuous-flow cell.The reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis.
ElectrochemistryContinuous-flowDearomatizationSpirocyclizationSulfonamidesCyclizationMethodology and reactions
Ting Liu、Zhaojiang Shi、Yaofeng Yuan、Yuqi Lin、Ke-Yin Ye
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Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University),College of Chemistry,Fuzhou University,Fuzhou,Fujian 350108,China
National Natural Science Foundation of ChinaHundred-Talent Project of Fujian
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