首页|Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

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Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds.Given the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis.Herein,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valu-able β-perfluoroalkylated amides with generally good yields and high chemoselectivity.

Visible lightPhotoredox catalysisRadical aminocarbonylationMulticomponent reactionCarbon monoxideUnactivated alkenesAmidesReaction mechanisms

Bin Lu、Feng-Shuo Bao、Zi-Wei He、Wen-Jing Xiao、Jia-Rong Chen

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Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction,College of Chemistry,Central China Normal University,152 Luoyu Road,Wuhan,Hubei 430079,China

Wuhan Institute of Photochemistry and Technology,7 North Bingang Road,Wuhan,Hubei 430083,China

Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province,Gannan Normal University,Ganzhou,Jiangxi 341000,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaDouble-Thousand Talents Plan of Jiangxi ProvinceOpen Research Fund of School of Chemistry and Chemical Engineering,Henan Normal UniversityProgram of Introducing Talents of Discipline to Universities of China(111 Program)

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2024

10.1002/cjoc.202300733

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(9)