首页|Recent Advances in C—F Bond Formation from Carbon-Centered Radicals
Recent Advances in C—F Bond Formation from Carbon-Centered Radicals
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Construction of C—F bonds is a direct and efficient method for introducing fluorine into pharmaceuticals,agrochemicals,and mate-rials.Strategies such as nucleophilic,electrophilic,radical,and transition-metal catalyzed fluorination have been developed to meet the demand of diverse C—F bond formation.Among them,radical fluorination has been witnessed with substantial advancement in a recent decade.Herein,we reviewed methods for formation of C—F bonds with carbon-centered radicals as key intermediates,es-pecially in recent five years.We introduce in the paper with different fluorinating reagents,strategies for radical generation,and ap-plication in late-stage functionalization and synthesis of PET tracers.We also indicate the current limitations and propose the direc-tion of the field for the future development.
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