C-F Bond Insertion into Indoles with CHBr2F:An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones

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外文摘要：A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharma-ceuticals,materials,and organic synthesis,was described through C-F bond insertion into indoles using CHBr2F.The simple condi-tions,readily availability of CHBr2F,as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and 3-fluoroquinolone.The mechanistic studies reveal that bromofluorocarbene generated in-situ under basic condition was the key intermediate.

外文关键词：

Skeleton editFluorocarbeneRing expansionQuinolineQuinolone

作者：

Chao Li、Lei Chen、Hongye Wang、Zixi Yan、Bin Lyu、Weiping Lyu、Changwei Jiang、Dehua Lu、Jiaxing Li、Ning Jiao、Song Song

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作者单位：

State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Xue Yuan Rd.38,Beijing 100191,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaPeking University Medicine Fund for world's leading discipline or discipline cluster development

项目编号：

2237100722071005BMU2022DJXK002

出版年：

2024

DOI：

10.1002/cjoc.202400033

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(10)