Recent Advances in Deuteration Reactions

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外文摘要：The deuteration of organic compounds has attracted more attentions in recent years for the potential applications in new drug dis-covery and synthetic chemistry.For this purpose,many efficient deuterium labeling methodologies have been developed,including hydrogen isotope exchange(HIE),reductive deuteration,and dehalogenative deuteration that allow for the synthesis of selectively deuterated compounds.In the last few years,great breakthroughs in selective isotope labeling have been achieved and the interest in new methodologies for the deuteration of organic molecules is rising.In this review,we summarized the recent developments in the selective deuteration of organic molecules since 2021.Several types of key processes in deuterium incorporation reactions,in-cluding H/D exchange,reductive deuteration and dehalogenative deuteration,are introduced and discussed.

外文关键词：

Deuterated compoundsH/D exchangeReductive deuterationsDehalogenative deuterationsDeuteriumC-H activationSynthetic methods

作者：

Hao Li、Muhammad Shabbir、Wu Li、Aiwen Lei

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作者单位：

Institute for Advanced Studies(IAS),College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China

基金：

National Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience Foundation of Wuhan

项目编号：

2021YFA1500100220310082122000072020010601012192

出版年：

2024

DOI：

10.1002/cjoc.202300570

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(10)