Organic Synthesis through Radical Innovation:Frustrated Radical Pairs

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外文摘要：Frustrated Lewis Pairs(FLPs)represent a unique class of interactions in Lewis acid-base chemistry,driven by spatial hindrance or in-congruent orbital energy levels that hinder the formation of effective coordination bonds.FLPs have received significant attention for their application in activating small molecules and facilitating organic synthesis reactions.Recent developments have led to the emergence of Frustrated Radical Pairs(FRPs)as an extension of the radical family.FRPs are formed from FLPs through Single Electron Transfer(SET)and exhibit the ability to activate a variety of chemical bonds.While research on FLPs is well-established,investiga-tions into FRPs in organic reactions remain limited.This review highlights the current state of FRPs in organic synthesis,delves into mechanistic insights,explores their potential,and underscores the challenges in this emerging field.

外文关键词：

RadicalsFrustrated Lewis PairsFrustrated Radical PairsMethodology and reactionsReaction mechanisms

作者：

Zhibin Hu、Zengrui Cheng、Ning Jiao

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作者单位：

State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

Shanghai Key Laboratory of Green Chemistry and Chemical Processes,East China Normal University,Shanghai 200062,China

基金：

National Key R&D Program of ChinaNSFCNSFCNSFCNSFCNew Cornerstone Science Foundation through the New Cornerstone Investigator Program and the XPLORER PRIZE

项目编号：

2021YFA150170022293014221310022216114201981821004

出版年：

2024

DOI：

10.1002/cjoc.202300665

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(10)