首页|Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of tumor.Such barrier sig-nificantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stro-mal barrier for improved tumor therapy with deep penetration ability.To achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles'physicochemical properties(i.e.,size,surface charge,and morphology),me-chanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing nanomedicine.All these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were included.With the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new op-portunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

NanomedicineTumor stromaDeep penetrationEnhanced drug perfusionCancer therapyDrug carriersBiomaterialsNanotechnology

Guo-Feng Luo、Wei-Hai Chen、Xian-Zheng Zhang

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State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School & Hospital of Stomatology,Wuhan University,Wuhan,Hubei 430079,China

Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry,Wuhan University,Wuhan,Hubei 430072,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHubei Province Health and Family Planning Scientific Research ProjectTranslational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,China

2022YFB3804600523032055207321852273301221350055187316251988102WJ2023Q011ZNJC202224

2024

10.1002/cjoc.202300642

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(10)