首页|Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues

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The structural and surface properties of nanomedicines play an important role in determining their biological fate.Surface chemistry of nanomedicines is one of the key parameters,where researchers used various strategies such as PEGylation to avoid the undesired clearance of nanoparticles(NPs)for enhanced targeting effect.Nevertheless,the fine-tuning of surface chemistry through polymer functionalization remains largely unexplored.In this concise report,we find that the incorporation of only 10 mol％valine residues into the surface-anchored poly(L-glutamic acid)significantly lowered the macrophage uptake of NPs.The introduction of other hy-drophobic amino acid residues,however,increased the NPs internalization instead.The chirality and the side-chain structure of va-line played an important role in the unexpected uptake behavior.We believe this work highlights the impact of slight changes of the surface-anchored polymer structure on the behavior of NPs,drawing people's attention to the careful design of surface chemistry to optimize the nanomedicine design.

NanoparticlesCopolymersStructure-activity relationshipsSurface chemistryPolypeptideMacrophage uptake

Ning Li、Shanshan Xiao、Xiaoxiong Jin、Ziyuan Song

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Institute of Functional Nano & Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou,Jiangsu 215123,China

National Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu ProvinceSuzhou Municipal Science and Technology BureauCollaborative Innovation Center of Suzhou Nano Science & Technology111 ProjectJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSuzhou Key Laboratory of Nanotechnology and Biomedicine

22101194BK20210733ZXL2021447

2024

10.1002/cjoc.202300724

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(11)