首页|Visible-Light-Mediated Photocatalyst-Free Hydroacylation of Azodicarboxylic Acid Derivatives with 4-Acyl-1,4-dihydropyridines
Visible-Light-Mediated Photocatalyst-Free Hydroacylation of Azodicarboxylic Acid Derivatives with 4-Acyl-1,4-dihydropyridines
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A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(acyl-DHP)reagents that besides being as radical reservoirs,they also enabled the conversion of radical adducts to anion intermediates via reduction.Under"cata-lyst-oxidant-additive free"conditions,a wide range of structurally different acyl hydrazide products were readily obtained in 56％-99％yields.The utility of this transformation was further demonstrated by the scale-up synthesis and downstream derivatiza-tion.
Li Liu、Jing Wang、Xiaoying Feng、Kun Xu、Wei Liu、Xia Peng、Hongguang Du、Jiajing Tan
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Department of Organic Chemistry,College of Chemistry Beijing University of Chemical Technology,Beijing 100029,China
Sinopec Beijing Research Institute of Chemical Industry,Beijing 100013,China
Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China
National Natural science Foundation of ChinaNational Natural science Foundation of ChinaFundamental Research Funds for the Central Universities at the BUCT
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