Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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外文摘要：The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be explored.In this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was established.Ronga-lite,a safe and inexpensive industrial product,was employed as both a radical initiator and reductant.This procedure was compati-ble with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(＞70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

外文关键词：

DefluoroarylationTransition metal freegem-DifluoroalkenesRongaliteSingle electron transferC-C couplingRedox reactionsCross-coupling

作者：

Xiang-Long Chen、Chun-Yan Wu、Dong-Sheng Yang、Bo-Cheng Tang、Huai-Yu Wang、Zhi-Cheng Yu、Anling Li、Yan-Dong Wu、An-Xin Wu

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作者单位：

National Key Laboratory of Green Pesticide,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan,Hubei 430079,China

State Key Laboratory of Chemical Biology and Drug Discovery,Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Kowloon,Hong Kong SAR,China

Department of Clinical Laboratory,Center for Gene Diagnosis,and Program of Clinical Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan,Hubei 430062,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China111 Project

项目编号：

219710802197107921772051B17019

出版年：

2024

DOI：

10.1002/cjoc.202300751

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(12)