首页|Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent-Free Conditions
Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent-Free Conditions
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The development of switchable solvent-free multicomponent reactions to build high-value-added products is an important demand for organic synthesis.Herein,we detailed the successful implementation of a switchable strategy for the construction of diverse 4-fluoroalkyl-1,4-dihydropyrimidines and 4-fluoroalkyl-pyrimidines via a solvent/additive-free[3+2+1]annulation,starting from readily available enamines,trifluoroacetaldehyde hydrate or 1-ethoxy-2,2-difluoroethanol and amidines hydrochloride.This reaction conforms to the concept of green synthesis,and provides a new avenue to access valuable fluorinated heterocycles.
Wanqing Zuo、Zhizhen Zhu、Yu Cheng、Lingling Zuo、Xiao Geng、Zhifang Li、Lei Wang
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College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China
Advanced Research Institute and School of Pharmaceutical Sciences,Taizhou University,Jiaojiang,Zhejiang 318000,China
State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China
National Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province
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