首页|Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives:Construction of C-N Axially Chiral Sulfides

Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives:Construction of C-N Axially Chiral Sulfides

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Chiral BINAM-derived selenide/achiral acid co-catalyzed atroposelective electrophilic sulfenylation of pyrrole derivatives has been re-alized for the first time.A variety of C-N axially chiral sulfur-containing pyrrole derivatives were readily obtained in moderate to good yields with moderate to excellent enantioselectivities.This catalytic system involves sequential desymmetrization and kinetic resolu-tion.

Electrophilic substitutionDesymmetrizationKinetic resolutionAtropisomerismAsymmetric catalysisHeterocycles

Qin Yang、Hui-Yun Luo、Deng Zhu、Xin-Yu Zhang、Hua Ke、Zhi-Min Chen

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School of Chemistry and Chemical Engineering,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,Shanghai Jiao Tong University,Shanghai 200240,China

Engineering Technology Research Center for Environmental Protection Materials,Pingxiang University,Pingxiang,Jiangxi 337055,China

State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China

2024

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子:0.848
ISSN:1001-604X
年,卷(期):2024.42(17)