Copper/Photoredox-Catalyzed Regioselective 1,4-Addition to 1,3-Enynes:A Convenient Access to Perfluoroalkylated Allenes

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外文摘要：A general and broadly applicable copper and photoredox dual-catalyzed multicomponent 1,4-perfluoroalkylcyanation of 1,3-enynes has been developed.This protocol enjoys success with high regioselectivity,mild reaction conditions,and excellent functional-group tolerance,allowing the facile synthesis of structurally diverse perfluoroalkylated allenes from readily available fluoroalkyl halides,1,3-enynes and TMSCN in a one-pot manner.A reasonable mechanism has been proposed according to a series of control experi-ments.

外文关键词：

Fluorinated allenes1,3-EnynesPhotoredoxFluoroalkylationMulticomponent reactionsDifunctionalizationRadicalsRegioselectivity

作者：

Ya Chen、Quanyuan Wang、Keyi Peng、Lilei Cheng、Ziyi She、Guo-Jun Deng

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作者单位：

Key Laboratory for Green Organic Synthesis and Application of Hunan Province,Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan,Hunan 411105,China

Department School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

出版年：

2024

DOI：

10.1002/cjoc.202400207

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(17)