首页|I2-DMSO-Mediated Multicomponent[2+1+1+1]Annulation Reaction via Ethyl Nitroacetate C—NO2 Bond Cleavage as a C1 Synthon:A Route to Multisubstituted β-Pyrrolidinones Derivatives with a Quaternary Center
I2-DMSO-Mediated Multicomponent[2+1+1+1]Annulation Reaction via Ethyl Nitroacetate C—NO2 Bond Cleavage as a C1 Synthon:A Route to Multisubstituted β-Pyrrolidinones Derivatives with a Quaternary Center
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A[2+1+1+1]cyclization reaction has been developed for the synthesis of multisubstituted β-pyrrolidinones from commercially available aryl methyl ketones,primary amines,and ethyl nitroacetate.In this l2-DMSO-meditated process,the C—NO2 bond of ethyl nitroacetate is cleaved,affording a C1 synthon,and the formation of two C—C and two C—N bonds and a quaternary carbon center are constructed in one pot.This method has good substrate compatibility and permits the late-stage modification of pharmaceutical compounds.
CyclizationMultisubstituted β-pyrrolidinonesI2-DMSOC1 building blocksQuaternary carbon centerLate-stage modificationCracking
National Key Laboratory of Green Pesticide,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan,Hubei 430079,China
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