首页|Emerging Bio-relevant Applications of Polymer Mechanochemis-try
Emerging Bio-relevant Applications of Polymer Mechanochemis-try
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Polymer mechanochemistry has rapidly evolved since the mid-2000s.Recent advancements highlight the development of mech-anophore platforms for the controlled release of bioactive payloads and the exploration of biocompatible activation strategies.The-se platforms,ranging from furan-maleimide Diels-Alder adducts to disulfide motifs with β-carbonate linkages,demonstrate promis-ing prospects in targeted drug delivery.Additionally,supramolecular assemblies and free radical-generating mechanophores present innovative avenues for potential therapeutic applications.Biocompatible activation methods,notably high-intensity and/or low-intensity focused ultrasound,hold potential for in vivo applications.However,challenges persist in comprehending the funda-mental physics of ultrasound and its utilization for activation.Future directions emphasize the importance of simplicity in biocom-patible platforms and polymer designs,stability under physiological conditions,and precise control of mechanical activation for en-hanced biomedical and clinical utility.Despite the aforementioned chemical and technical obstacles,the outlook for polymer mech-anochemistry in biomedical and clinical applications remains promising,urging continued exploration and advancement.
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