首页|De novo Synthesis of Chiral 3,4-Dihydroquinazolines via One-Pot Enantioselective Ugi-Azide/Cyclization Sequences
De novo Synthesis of Chiral 3,4-Dihydroquinazolines via One-Pot Enantioselective Ugi-Azide/Cyclization Sequences
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Herein,we reported a precise de novo synthesis of chiral 3,4-dihydroquinazoline frameworks via a one-pot anionic stereogen-ic-at-cobalt(Ⅲ)complex-catalyzed enantioselective Ugi-azide/Pd-catalyzed cyclization sequence.This powerful protocol involves 5 components and 2 catalytic systems,delivering chiral 3,4-dihydroquinazolines with excellent enantioselectivities(up to 94％ee).The preliminary antifungal experiments suggest that both Ugi-adducts and 3,4-dihydroquinazolines have great potential in inhibiting plant pathogens such as Trichoderma viride and Fusarium graminearum.
Anionic stereogenic-at-cobalt(Ⅲ)complexDe novo synthesispost-Ugi transformationOne-pot sequenceAsymmetric synthesisMulticomponent reactions
Department of Applied Chemistry,Anhui Province Engineering Laboratory for Green Pesticide Development and Application,and Anhui Province Key Laboratory of Crop Integrated Pest Management,Anhui Agricultural University,Hefei,Anhui 230036,China
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