Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Epigenetic Modification

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外文摘要：DNA 5-formylcytosine(5fC)is a prominent epigenetic modification within biological systems.Recent investigations have shed light on its pivotal role in governing cell fate,gene expression,and disease pathways.However,our comprehension of the precise control of the 5fC site structure to influence its functionality remains limited.In this study,we have successfully achieved precise control over 5fC activity by harnessing the interaction between streptavidin and biotin.This research underscores the potential application of interac-tions between biomacromolecules and small molecules in advancing the field of DNA epigenetic functional regulation.

外文关键词：

Epigenetic modificationBiotinStreptavidinSelectivityRegulation

作者：

Yongjie Liu、Xinyan Xu、Xingyu Liu、Wei Xiong、Qianqian Qi、Yuanyuan Zhang、Jinxuan Hou、Tian Tian、Xiang Zhou

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作者单位：

Key Laboratory of Biomedical Polymers of Ministry of Education,College of Chemistry and Molecular Sciences,Hubei Province Key Laboratory of Allergy and Immunology,Wuhan University,Wuhan,Hubei 430072,China

Department of Thyroid & Breast Surgery,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan,Hubei 430072,China

出版年：

2024

DOI：

10.1002/cjoc.202400236

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(18)