Hyperlanins A and B,Two Highly Rearranged Meroterpenoids from Hypericum lancasteri

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外文摘要：Hyperlanins A(1)and B(2),two highly rearranged polycyclic polyprenylated acylphloroglucinol(PPAP)-related meroterpenoids based on different new carbon skeletons,were isolated from Hypericum lancasteri.Compound 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13-dioxatetracyclo[9.2.1.12,5.01.8]pentadecane core.Compound 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.2.1.13,8.05,11]dodecane motif.Their structures were established by spectroscopic data,X-ray dif-fraction,and computational approaches.Both compounds showed anti-inflammatory activity in vitro.Compounds 1 and 2 could de-crease the lipopolysaccharide(LPS)-/nigericin-induced IL-1β release in THP-1 cells.Both compounds also showed inhibition in hypox-ia-inducible factor-1α(HIF-1α)pathway luciferase reporter assay.

外文关键词：

Natural productsHypericum lancasteriMeroterpenoidsStructure elucidationInflammation

作者：

Jin-Qiu You、Yun-Qi Jin、Meng-Yu Li、Bo-Chao Zhang、Xin-Yu Sun、Chun-Yong Ding、Jing-Ya Li、Ai-Jun Hou

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作者单位：

Shanghai Frontiers Science Center of Drug Target Identification and Delivery,School of Pharmaceutical Sciences,Shanghai Jiao Tong University,Shanghai 200240,China

National Key Laboratory of Innovative Immunotherapy,Shanghai Jiao Tong University,Shanghai 200240,China

Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Shanghai Institute of Materia Medico,Chinese Academy of Sciences,Shanghai 201203,China

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出版年：

2024

DOI：

10.1002/cjoc.202400248

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(18)