首页|Electron Reservoir MoO3-x-Driven Cu+Doped Nanozyme with Enhanced Antibacterial Activity via Disrupting Redox Homeostasis
Electron Reservoir MoO3-x-Driven Cu+Doped Nanozyme with Enhanced Antibacterial Activity via Disrupting Redox Homeostasis
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Redox nanozymes offer an appealing reactive oxygen species(ROS)-based antibacterial strategy via disrupting intracellular homeosta-sis,however,they still face many obstacles such as low enzymic activity and irreversible loss of catalytic active center.Meanwhile,the antioxidant glutathione(GSH)overexpressed in infected sites would limit the therapy efficiency.Herein,we develop a multifunctional nanozyme based on copper(Ⅰ)(Cu+)ion doped MoO3-x(Cu+-MoO3-x)by a simple yet efficient oxygen vacancy-reduced strategy without any pretreatment or additional agents.The resultant Cu+-MoO3_x hybrid possesses enhanced peroxidase-like(POD-like)activity,rapid GSH-depleting function and biodegradable ability.It can achieve highly efficient elimination of Pseudomonas aeruginosa(P.aerugino-sa)via disrupting cellular redox balance.More intriguingly,GSH-depleting redox reaction between Cu+-MoO3-x and GSH could trans-late Mo6+into Mo5+,thereby leading to partial recovery of POD-like activity of Cu+-MoO3-x hybrid for continuous·OH generation.In vitro and in vivo experiments demonstrated that Cu+-MoO3_x hybrid had stronger antibacterial property compared to MoO3-x by rapid GSH consumption and plentiful OH generation without providing extra H2O2,as well as neglective toxicity to healthy organs.In view of its remarkable enzymic activity and good biosafety,the developed Cu+-MoO3-x redox nanozyme can be used as a promising antimicro-bial for P.aeruginosa infection.
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