首页|Nickel/Photoredox Dual Catalytic Chan-Lam Coupling of Aryl Azides and Arylboric Acids
Nickel/Photoredox Dual Catalytic Chan-Lam Coupling of Aryl Azides and Arylboric Acids
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Unsymmetrical diarylamines are crucial components in many pharmaceuticals and functional materials.In this study,we introduce an efficient Chan-Lam cross-coupling method that utilizes phenylboronic acids and aryl azides as coupling agents in a redox-neutral envi-ronment,enabled by a synergistic nickel/photoredox catalytic system.This approach leverages a proton-coupled electron transfer mechanism to bypass the typical nitrene pathway associated with aryl azides,which is prone to intramolecular rearrangement,C-H amination,and reductive hydrogenation.Notably,our method exhibits broad compatibility with a variety of functional groups,includ-ing those derived from pharmaceuticals,demonstrating its versatile potential in organic synthesis and drug modification.
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