首页|Visible-Light-Induced Domino Cyclization to Access Pyrido[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction

Visible-Light-Induced Domino Cyclization to Access Pyrido[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction

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Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crosso-ver(RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization.The reaction exhibited a broad substrate scope(＞40 examples)including complex molecules,which highlighted the utility of this strategy for the construction of a library of bioactive analogs.

PhotocatalysisHeterocyclesRadicalsBromodifluoroalkyls6-AminouracilesEnaminones

Wanqing Zuo、Yu Cheng、Zhizhen Zhu、Lingling Zuo、Xiao Geng、Zhifang Li、Lei Wang

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Advanced Research Institute and School of Pharmaceutical Sciences,Taizhou University,Jiaojiang,Zhejiang,318000,China

College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China

2024

10.1002/cjoc.202400315

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(19)