Characterization of HpnG as a Purine Nucleoside Phosphorylase in Bacteriohopanepolyol Biosynthesis

扫码查看

原文链接

万方数据
维普

外文摘要：HpnG plays a crucial role in the production of ribosylhopane,a key intermediate in the biosynthesis of bacteriohopanepolyol.De-spite early extensive studies,the precise function of HpnG has remained elusive.Here,we report functional characterization of HpnG as a purine nucleoside phosphorylase,which converts adenosylhopane to phosphoribosylhopane in the presence of phos-phate.HpnG demonstrates broad substrate specificity and impressive stability,making it a valuable enzymatic tool for applications in nucleoside processing and related biotechnology.

外文关键词：

EnzymesEnzyme catalysisNucleosidesBiosynthesisNatural productsLipidsPhosphorolysisBiotransformations

作者：

Xinhui Li、Xiaoyu Zhu、Yuting Zhong、Wei Zhang、Fener Chen、Wenning Wang、Wei Ding、Qi Zhang

展开 >

作者单位：

Department of Chemistry,Fudan University,Shanghai 200433,China

State Key Laboratory of Microbial Metabolism,School of Life Sciences & Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China

Key Laboratory of Extreme Environmental Microbial Resources and Engineering of Gansu Province,Northwest Institute of Eco-Environment and Resources,Chinese Academy of Sciences,Lanzhou,Gansu 73000,China

出版年：

2024

DOI：

10.1002/cjoc.202400233

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(19)