Palladium-Catalyzed Selective Syntheses of 2,3-Allenyl Amines via Double Functionalization Coupling of 2-Alkynyl-1,4-diol Dicarbonates

扫码查看

原文链接

万方数据
维普

外文摘要：2,3-Allenyl amines have shown wide applicability in biomedical and synthetic applications.Due to their enormous potential for appli-cations,researchers have been dedicated to the development of methods for synthesizing 2,3-allenyl amines.Herein,a palladi-um-catalyzed three-component reaction of 2-alkynyl-1,4-diol dicarbonates,organoboronic acids,and nitrogen nucleophiles forming 2,3-allenyl amines with excellent regio-and chemo-selectivity has been developed.Substrate compatibility and synthetic applications have been demonstrated.Control experiments supported a mechanism involving 1,2,3-triene-Pd species and methylene-π-allyl palla-dium species.

外文关键词：

Pd catalysis2,3-Allenyl amineAlk-2-yn-1,4-diol dicarbonateOrganoboronic acid1,2,3-TrieneMethylene-π-allyl palladium speciesRegioselectivityChemoselectivity

作者：

Zhengnan Zhou、Can Li、Shengming Ma

展开 >

作者单位：

State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032,China

University of Chinese Academy of Sciences,Beijing 100049,China

Research Center for Molecular Recognition and Synthesis,Department of Chemistry,Fudan University,220 Handan Lu,Shanghai 200433,China

出版年：

2024

DOI：

10.1002/cjoc.202400298

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(19)