Palladium/Xu-Phos Catalyzed Enantioselective Intramolecular Heck Reaction of Unactivated Alkenes

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外文摘要：A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research.Its salient features include high yield,excellent chemo-and enantioselectivity,mild conditions,a broad substrate scope as well as versatile transformations of the product.

外文关键词：

PalladiumHeck2,3-DihydrobenzofuranAsymmetric catalysisQuaternary stereocenterEnantioselectiveP ligandsAlkenes

作者：

Lujia Zhou、Longling Ma、Bing Xu、Zhan-Ming Zhang、Junliang Zhang

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作者单位：

Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai 200438,China

Zhuhai Fudan Innovation Institute,Zhuhai,Guangdong 519000,China

Fudan Zhangjiang Institute,Shanghai 201203,China

School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

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出版年：

2024

DOI：

10.1002/cjoc.202400391

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(20)