首页|Visible Light Catalyzed Reductive Cross-Coupling of α-CF3-alkyl Bromide and Alkynyl Bromide
Visible Light Catalyzed Reductive Cross-Coupling of α-CF3-alkyl Bromide and Alkynyl Bromide
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
Traditional reduction coupling reactions of two bromides typically rely on transition metal catalysis.Here,we introduce the development of a visible-light catalytic direct reduction coupling reaction between α-CF3-alkyl bromides and alkynyl bromides to access valuable organic frameworks.Our research confirms the excellent compatibility of this reaction with various functional groups,which could be used to modify the substrate with biologically active molecular fragments.Mechanistic investigations,including control experiments,fluorescence quenching studies,and light-switching experiments,have provided insights into the reaction mechanism.This study paves the way for the application of visible-light catalysis in diverse synthetic transformations,offering a sustainable and efficient approach to organic synthesis.
Visiable light catalysisC-C bond formationReductive cross-couplingTrifluoromethyl groupAlkynyl groupRadicalsOrganohalidesPhotochemistry
Yiqiang Tian、Yi Li、Chun Zhang
展开 >
Institute of Molecular Plus,Department of Chemistry,School of Pharmaceutical Science and Technology,Faculty of Medicine,Tianjin University,92 Weijin Road,Tianjin 300072,China
万方数据
