Rhodium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Amides:Efficient Access to Chiral β-Amino Amides

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外文摘要：The first asymmetric hydrogenation of acyclic tetrasubstituted α,β-unsaturated amides has been achieved by using Rh/DuanPhos complex as a catalyst,delivering chiral β-amino amides with two contiguous chiral centers in excellent yields and high enantioselectivi-ties(up to 99％yield,96％ee),which provides efficient and concise access to valuable β-amino amide derivatives.The gram-scale re-action and efficient transformation of β-amino amide to β-amino acid and β-amino cyanide demonstrated the utility of this method-ology.

外文关键词：

Asymmetric hydrogenationβ-Amino amidesAsymmetric catalysisContiguous chiral centersRhodiumAminesReductionEnantioselectivity

作者：

Bing Jiao、Fangyuan Wang、Hui Lv

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作者单位：

State Key Laboratory of Power Grid Environmental Protection

Hubei Key Lab on Organic and Polymeric Optoelectronic Materials

Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education

Key Laboratory of Biomedical Polymers of Ministry of Education&College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China

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出版年：

2024

DOI：

10.1002/cjoc.202400344

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(21)