Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters

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外文摘要：Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furthermore,the utilization of catalysts based on abundant elements found on Earth for alcohol dehydrogenation to produce acryl ketone holds significant promise as a versatile strategy in synthesizing key building blocks for numerous pharmaceutical applications.The present study describes a practical Co-catalyzed cascade dehydrogenative Claisen condensation of secondary alcohols with esters,facilitating the synthesis of a wide range of 3-hydroxy-prop-2-en-1-ones.We introduce a catalytic system based on novel and scalable indazole NNP-ligands coordinated to cobalt for efficient dehydrogenations of secondary alcohols,and propose a plausible reaction mechanism supported by control experiments and labeling studies.Notably,it allows for the streamlined synthesis of multiple pharmaceuticals in one-pot.

外文关键词：

CobaltPincer LigandDehydrogenationClaisen Condensation3-Hydroxy-prop-2-en-1-oneAlcohols3d transition metalsEnolsEnones

作者：

Shuo Gao、Wentao Hao、Yuqi Ji、Xiulin Li、Chunyan Zhang、Guoying Zhang

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作者单位：

State Key Laboratory of Coal Conversion,Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan,Shanxi 030001,China

University of Chinese Academy of Sciences,Beijing 100049,China

College of Ecology,Taiyuan University of Technology,Taiyuan,Shanxi 030001,China

出版年：

2024

DOI：

10.1002/cjoc.202400481

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(22)