首页|Enantioselective Total Synthesis of(+)-Propolisbenzofuran B

Enantioselective Total Synthesis of(+)-Propolisbenzofuran B

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The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hy-drogenation of a tetrasubstituted olefin,was described.Other noteworthy aspects include the construction of the central hydrodi-benzo[b,d]furan core through a sequence of Zn(Ⅱ)-mediated regioselective benzofuran formation and Dieckmann condensation,as well as C-H oxidations,involving a visible light-induced Fe(Ⅲ)-catalyzed benzylic C(sp3)-H oxidation.Additionally,the absolute configu-ration was confirmed by X-ray analysis of a carbonate intermediate.

Propolisbenzofuran BTotal synthesisEnantioselective hydrogenationPhotocatalysisC—H functionalizationNatural productsAlkenesChirality

Wen-Xiu Xu、Li-Han Zhao、Yao Zhu、Hai-Hua Lu

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Department of Chemistry,Zhejiang University,866 Yuhangtang Road,Hangzhou,Zhejiang 310058,China

Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province,Department of Chemistry and Research Center for Industries of the Future,Westlake University,600 Dunyu Road,Hangzhou,Zhejiang 310030,China

Institute of Natural Sciences,Westlake Institute for Advanced Study,18 Shilongshan Road,Hangzhou,Zhejiang 310024,China

2024

10.1002/cjoc.202400563

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(22)