首页|Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain

Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain

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Although considerable progress has been achieved in treating iron-overload diseases with deferoxamine(DFO)-based biomaterials,high DFO loading and multifunctional integration in one system are still grand challenges.Herein,a series of carrier-free,high DFO-loading(～80％),uniform spherical nanoparti-cles(NPs)assisted by polyphenols have been facilely developed with both efficient iron and reactive oxy-gen species-scavenging properties.Interestingly,those DFO-based NPs have demonstrated excellent scavenging performance in iron-overloaded cell model and energetically exhibited brain cell protec-tion in vivo in intracerebral hemorrhage animal mod-els.This study could provide a promising strategy to significantly improve the curative effect of DFO de-livery systems for iron-overload diseases.

carrier-freedeferoxaminenanoparticlesiron scavengingreactive oxygen species scavenging

Fang Zhu、Jian Zhong、Junfei Hu、Peng Yang、Jianhua Zhang、Minghua Zhang、Yiwen Li、Zhipeng Gu

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College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu,Sichuan 610065

State Key Laboratory of Biotherapy and Cancer,West China Hospital,Sichuan University and Collaborative Innovation Center,Chengdu 610041

国家自然科学基金中央高校基本科研业务费专项

52173132

2023

10.31635/ccschem.022.202101696

中国化学会会刊(英文)

中国化学会会刊(英文)

CSCD
ISSN：
年,卷(期)：2023.5(1)
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