Chiral Bicyclic Imidazole-Catalyzed Direct Enantioselective C-Acetylation of Indolones

扫码查看

原文链接

NETL
NSTL
万方数据
维普

外文摘要：By adjusting the bond angle and stereocontrol sub-stituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Indolones bearing a quaternary stereocenter were synthesized with satisfactory yields and excellent enantioselectivities(up to 97％ee).The reaction can be realized with 410 turnover numbers,and the pro-ducts can be transformed into several functional com-pounds via simple derivations of the acetyl group.

外文关键词：

organocatalysisLewis baseenantioselec-tive acylationbicyclic imidazoleindoIone

作者：

Muxing Zhou、Yashi Zou、Lu Zhang、Zhenfeng Zhang、Wanbin Zhang

展开 >

作者单位：

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240

Frontier Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240

基金：

国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金上海市教委项目中国博士后科学基金Instrumental Analysis Center of Shanghai Jiao Tong University

项目编号：

2018YFE012680021831005918561062199111222071 150201701070002E000302021M692058

出版年：

2023

DOI：

10.31635/ccschem.022.202201782

中国化学会会刊(英文)

CSCD

ISSN：

年,卷(期)：2023.5(2)

参考文献量80