首页|Temperature and Tumor Microenvironment Dual Responsive Mesoporous Magnetic Nanospheres for Magnetothermal Effect-Induced Cancer Theranostics
Temperature and Tumor Microenvironment Dual Responsive Mesoporous Magnetic Nanospheres for Magnetothermal Effect-Induced Cancer Theranostics
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The development of smart drug delivery systems(SDDSs)based on engineered nanomaterials is im-portant for clinical applications.Nevertheless,con-trollable administration of chemotherapeutic drugs for deep tumors and the avoidance of side effects caused by off-targeting during delivery remain a great challenge.Herein,a stimulus-responsive sys-tem of mesoporous nanospheres(composed of Cu@Fe2C@mSiO2)with good magnetothermal ef-fect is introduced into the tumor microenvironment.This system plays an important role in image-guided controllable targeted drug delivery that is indepen-dent of tumor depth.Aggregation-induced emission luminogen-based fluorescence imaging and magnet-ic resonance imaging were utilized since these tech-niques visualize the delivery process in real time.In addition,the degraded nanocarriers showed high catalytic activity for Fenton and Fenton-like reac-tions,upregulating the level of hydroxyl radicals(·OH)in cancer cells to realize chemodynamic ther-apy.The induced·OH led to the overexpression of pho-STAT3,activating the STAT3 signaling pathway,eventually inducing cancer cell apoptosis.Through metabolic monitoring,this SDDS is removed from the body after its degradation in vivo.The synergistically enhanced therapeutic effect was obtained in the chemo-chemodynamic therapy of 4T1 tumor-bearing mice,offering a platform for efficient cancer therapy with a personalized theranostic strategy.
smart drug delivery systemsmagne-tothermal effectstimulus-responsive systemtumor microenvironmentchemo-chemodynamic therapy
Beijing Key Laboratory for Magnetoelectric Materials and Devices,School of Materials Science and Engineering,Peking University,Beijing 100871
Institute of Spin-X Science and Technology,South China University of Technology,Guangzhou 510641
School of Chemical and Materials Engineering,National University of Sciences & Technology,Islamabad 44000
Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032
Fifth Medical Center of Chinese PLA General Hospital,Beijing 100071
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维普
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