Photodynamic antibacterial therapy(PDAT)is a kind of rejuvenating strategy that combats bacterial infec-tion due to its admirable characteristics of noninva-siveness and broad-spectrum antibacterial capability.However,the efficiency of PDAT can be greatly hin-dered by limited light irradiation.Herein,we propose an enhanced PDAT by employing photonic composite films(PCFs)via slow photon and multiple scattering effects.The PCFs are obtained by UV light-initiated polymerization of poly(ethylene glycol)phenyl ether acrylate with a self-assembled SiO2 colloidal particle array,followed by the deposition of photosensitizers(PSs).The PCFs can prompt the PSs with matched absorption,which are deposited on their surface,to sufficiently utilize the incident light and generate more reactive oxygen species based on the slow photon phenomenon of photonic crystals and multiple scat-tering effects of the SiO2 colloidal particles.This find-ing demonstrates the great potential and significance of PCFs in the field of PDAT,which may reduce the requirements of excitation equipment and avoid damage to normal tissues from exposure to huge light energy.
Key Laboratory of Material Chemistry for Energy Conversion and Storage,Ministry of Education,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology(HUST),Wuhan 430074
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