首页|Biocompatible Chemically Fueled Transient Polymer Nanoparticles for Temporally Programmable in Vivo Imaging

Biocompatible Chemically Fueled Transient Polymer Nanoparticles for Temporally Programmable in Vivo Imaging

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Chemically fueled dissipative self-assembly paves the way for innovative materials with lifelike proper-ties and functions.Achievement of nonequilibrium systems with biocompatibility and biofunctions remains an important and challenging task.Here,we present biocompatible chemically fueled transient polymer nanoparticles and their applications in tem-porally programmable in vivo imaging.The lifetime of the transient polymer nanoparticles can be tuned by varying the concentration of polymer,adenosine triphosphate,and phosphatase.Moreover,the tran-sient assembly of polymer nanoparticles can be paused for storage and then subsequently restored.The transient polymer nanoparticles exhibit good biocompatibility.Notably,we implement in vivo im-aging in a temporally programmable fashion by using an autonomous fluorescence modulator of transient nanoparticles assembled from polymers with a fluorescence moiety.The results in this work provide a valuable way to achieve nonequilibrium self-assembly of synthetic systems with good biocompatibility and programmable biofunctions,accelerating innovative developments of nonequi-librium soft biomaterials.

polymer self-assemblynonequilibrium self-assemblypolymer nanoparticlesbiocompati-bilityprogrammable bioimaging

Chunyu Pan、Jiajun Xu、Liang Wang、Yiyang Jia、Jiahui Li、Guancheng Liu、Shoujun Zhu、Bai Yang、Yunfeng Li

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State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012

国家自然科学基金

21972054

2023

10.31635/ccschem.022.202201893

中国化学会会刊(英文)

中国化学会会刊(英文)

CSCD
ISSN：
年,卷(期)：2023.5(3)
  • 59