首页|Diastereoselective and Enantioselective Nickel-Catalyzed Reductive Coupling of Imines and Unactivated Alkenes

Diastereoselective and Enantioselective Nickel-Catalyzed Reductive Coupling of Imines and Unactivated Alkenes

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Herein we report a method for highly diastereoselec-tive and enantioselective nickel-catalyzed reductive coupling of imines and unactivated alkenes.A mono-dentate chiral spiro phosphoramidite ligand is the key to controlling the enantioselectivity.This efficient,straightforward method allows for the construction of chiral benzocyclic and indole-fused cyclic amines with two contiguous stereogenic centers in good yields from readily accessible starting materials.

nickel catalysisenantioselectivealkenesiminesreductive coupling

Biao Wang、Xian-Ming Liu、Kai-Xiang Zhang、Wei-Min Feng、Li-Jun Xiao、Qi-Lin Zhou

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State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071

国家自然科学基金国家自然科学基金国家自然科学基金中央高校基本科研业务费专项Haihe Laboratory of Sustainable Chemical Transformations for their financial support

217903329195600022188101

2023

10.31635/ccschem.022.202202506

中国化学会会刊(英文)

中国化学会会刊(英文)

CSCD
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年,卷(期)：2023.5(4)
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