首页|Visible Light Promoted Direct Deuteration of Alkenes via Co(Ⅲ)-H Mediated H/D Exchange

Visible Light Promoted Direct Deuteration of Alkenes via Co(Ⅲ)-H Mediated H/D Exchange

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We report herein a visible light-mediated direct deu-teration of alkenes with D2O or deuterated methanol(MeOD)using a cobaloxime as a hydrogen/deuteri-um(H/D)exchange catalyst.The synergistic photoredox/Co catalysis enabled facile deuterium(D)-incorporation of a variety of terminal and internal alkenes at either terminal or benzylic positions.We proposed that this process proceeded through a sequence of reversible addition-elimination reac-tions and fast proton exchange involving Co(Ⅲ)-H,which was generated in situ by photoreduction.

deuterationcobaloximehydrogen iso-tope exchangealkyl cobaltphotoredox

Zongbin Jia、Sanzhong Luo

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Department of Chemistry,Center of Basic Molecular Science(CBMS),Tsinghua University,Beijing 100084

国家自然科学基金国家自然科学基金国家自然科学基金清华大学自主科研项目Haihe Laboratory of Sustainable Chemical Transformations for financial support

919560002203100621861132003

2023

10.31635/ccschem.022.202202476

中国化学会会刊(英文)

中国化学会会刊(英文)

CSCD
ISSN：
年,卷(期)：2023.5(5)
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