首页|Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
国家科技期刊平台
NETL
NSTL
维普
万方数据
Excessive alcohol consumption leads to liver disease.Extensive evidence suggests that C-phycocyanin (C-PC),a chromophore phycocyanobilin derived from Spirulina platensis,exerts protective effects against chemical-induced organ damage.In this study,we investigated whether C-PC could protect against ethanol-induced acute liver injury.Serum alanine aminotransferase (ALT),aspartate arninotransferase (AST),triglyceride (TG),total cholesterol (CHOL),low-density lipoprotein (LDL),liver homogenate malondialdehyde (MDA),superoxide dismutase (SOD) content were measured,and pathological examination of liver sections were examined.C-PC showed obvious inhibitory effects on serum ALT,AST,TG,CHOL,LDL and MDA,and SOD content significantly increased in the liver.The structure of hepatic lobules was clear,liver sinus returned to normal,and liver cell cords were arranged in neat rows.Cloudiness,swelling,inflammatory cell infiltration and spotty necrosis of liver ceils were significantly reduced.Therefore,C-PC can significantly protect against ethanol-induced acute liver injury.
School of Pharmacy, Yantai University, Yantai 264005, China
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
School of Basic Medical, Binzhou Medical University, Yantai 264003, China
National Special Research Fund for Non-Profit Marine SectorTaishan Scholar Program of Shandong Province
国家科技期刊平台
NSTL
维普
万方数据
