首页|Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2

Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2

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  • 国家科技期刊平台
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Two phenylquinolinones,including one new compound (1) and a previously isolated compound (2),were isolated from the ethyl acetate extracts of the fungus Aspergillus versicolor Y31-2,which was obtained from seawater samples collected from the Indian Ocean.The structures of these compounds were established by spectroscopic analyses.4-(3-Hydroxyphenyl)-3-methoxyquinolin-2(1H)-one (1) exhibited moderate cytotoxicity against MCF-7 (human breast carcinoma cell line) and SMMC-7721 (human liver cancer cell line) cells with IC50 values of 16.6 and 18.2 μmol/L,respectively.To the best of our knowledge,this study represents the first reported account of the isolation of compounds 1 and 2 as the secondary metabolites of the seawater derived fungus Aspergillus versicolor from the Indian Ocean.

phenylquinolinonesanti-tumorAspergillus versicolor

LI Peihai、FAN Yaqin、CHEN Hao、CHAO Yaxi、DU Ning、CHEN Junhui

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Key Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration(SOA), Qingdao 266000,China

National Basic Research Program of China (973Program)National High Technology Research and Development Program of China (863 Program)China Ocean Mineral Resources Research and Development AssociationPublic Welfare Project of SOABasic Scientific Fund for National Public Research Institutes of China

2015CB7559062013AA092901-2DY125-15-T-07201205027GY0213G12

2016

海洋湖沼学报(英文版)
中国海洋湖沼学会

海洋湖沼学报(英文版)

CSTPCDCSCDSCI
影响因子：0.386
ISSN：2096-5508
年,卷(期)：2016.34(5)
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