Antioxidant bisabolane-type sesquiterpenoids from algal-derived fungus Aspergillus sydowii EN-434

HU Xueyi ¹LI Xiaoming ²MENG Linghong ²WANG Bingui²

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作者信息

1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China;College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China
2. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China;Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
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Abstract

A new aromatic bisabolene-type sesquiterpenoid (7 S ,8 S )-8-hydroxysydowic acid ( 1 ), together with a pair of new bisabolene derivative (±)-(7 R* ,10 R* )-10-hydroxysydowic acid ( 2 ), as well as two known analogues hydroxysydonic acid ( 3 ) and sydowic acid ( 4 ) were isolated and identified from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia latiuscula . Their structures were elucidated by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), and quantum chemical electronic circular dichroism (ECD) calculations as well as comparison of the data with literature reports. Compound 1 exhibited potent DPPH free radical scavenging activity with IC 50 value of 113.5 μmol/L.

Key words

Aspergillus sydowii/algal-derived fungus/bisabolene-type sesquiterpenoid/antioxidant activity

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基金项目

Supported by the National Natural Science Foundation of China(Nos.31330009)

Supported by the National Natural Science Foundation of China(31600267)

出版年

2020

海洋湖沼学报(英文版)

中国海洋湖沼学会

海洋湖沼学报(英文版)

CSTPCDCSCDSCI

影响因子：0.386

ISSN：2096-5508

参考文献量17

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