首页|Bioactive chemical constituents from the marine-derived fungus Cladosporium sp.DLT-5

Bioactive chemical constituents from the marine-derived fungus Cladosporium sp.DLT-5

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A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2-16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium sp.DLT-5.NMR and HRESIMS spectra elucidation determined the planar structure of 1.Subsequent electronic circular dichroism(ECD)experiment assigned the absolute configuration of 1.Compounds 1,2,4-6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells SH-SY5Y.Five compounds(1,3-5,and 13)emerged resistance to protein tyrosine phosphatase lB(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50 value of 10.74±0.61 μmol/L)was found as a noncompetitive inhibitor for PTP1B.Surface plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick Cl Like 1(NPC1L1),which has been identified as significant therapeutic target for hypercholesteremia.In addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum capsici.Therefore,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

Cladosporium sp.marine-derived fungusneuroprotective effectsprotein tyrosine phosphatase 1B(PTP1B)Niemann-Pick C1 Like 1(NPC1L1)antifungal activity

Luting DAI、Qingyi XIE、Jiaocen GUO、Qingyun MA、Li YANG、Jingzhe YUAN、Haofu DAI、Zhifang YU、Youxing ZHAO

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College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China

Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences & Hainan Academy of Tropical Agricultural Resource,Haikou 571101,China

China Agriculture Research System of MOF and MARAFinancial Fund of the Ministry of Agriculture and Rural Affairs,China国家自然科学基金

CARS-21NFZX202181973568

2024

10.1007/s00343-023-3084-7

海洋湖沼学报(英文版)
中国海洋湖沼学会

海洋湖沼学报(英文版)

CSTPCD
影响因子：0.386
ISSN：2096-5508
年,卷(期)：2024.42(3)