Investigating the Role and Mechanisms of Endogenous Retroviruses in Human Health and Aging
The activation of endogenous retrovirus(ERV)elements is involved in the regulation of related gene expression at specific developmental stages,such as early embryonic development and placental formation.Subsequently,under the surveillance of epigenetic regulation and other factors,ERVs remain transcriptionally silent in post-embryonic developmental stages.Aberrant ERV transcriptional activation is associated with the occurrence and development of multiple diseases such as cancers,neurodegeneration disorders,and autoimmune diseases.However,the role and underlying molecular mechanism of ERV in aging are still unclear.By the combination of interdisciplinary techniques in multiple aging models across cells,tissues,and species,researchers have revealed the unique roles of ERV reactivation as a biomarker and driving force of aging.Moreover,novel intervention strategies targeting ERVs have been developed to alleviate the degeneration and aging of tissues and organs.This progress expands the understanding of programmed cellular senescence,laying a theoretical foundation for alleviating aging and aging-related diseases.
endogenous retrovirusagingaging-related diseaseshuman health
NETL
NSTL
万方数据
