Research Progress on the Mechanisms of Birth Defects Caused by Metabolite Signaling Disorders
Metabolites are not only substrates and products of biological processes,but can also be perceived as signaling molecules by specific signal sensors,which in turn regulate specific biological processes and influence the occurrence of diseases such as tumors,diabetes and birth defects.This paper reviews the research progress on the mechanisms of birth defects caused by metabolite signaling disorders,and summarizes that cellular metabolites such as vitamins,amino acids and lipids affect the occurrence of birth defects by regulating genomic methylation,cell signal transduction,protein post-translational modification and/or enzyme activity regulation,which are expected to provide usable molecular targets for the prevention and treatment of birth defects.
NETL
NSTL
万方数据
