Construction of Engineered Exosomes Targeting Bladder Cancer Based on Bld-1 Short Peptide
This paper focused on the construction of engineered exosomes targeting bladder cancer based on Bld-1 short peptide.Using the short peptide Bld-1,the engineered exosomes of LAMP2B/Bld-1 were constructed by transfecting with LAMP2B/Bld-1 fusing expression plasmids.The feasibility of LAMP2B/Bld-1 engineered exosomes application in bladder cancer was further evaluated through exosome uptake experiment.The results showed that the LAMP2B/Bld-1 engineered exosomes could specifically target bladder cancer cell lines and serve as drug carriers to deliver drugs directly to bladder cancer cells.It is feasible to construct engineered exosomes targeting bladder cancer cells based on Bld-1 short peptide,which provides a new research direction and treatment strategy for patients with bladder cancer.
Bld-1 short peptidebladder cancerengineered exosomesLAMP2B protein
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