首页|Chirality discerning and monitoring in a metal cladding optofluidic chip

Chirality discerning and monitoring in a metal cladding optofluidic chip

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The metabolic process of chiral drugs plays a significant role in clinics and in research on drugs.Here,we experimentally demonstrate by all-optical means that the chiral molecules can be quickly discriminated and monitored with the ultrahigh-order modes excited in a metal cladding optofluidic chip,achieving over 5 times sensitivity with a low-dosage sample.We show that the varying concentration of the chiral drugs can be monitored both in cell and animal experiments,presenting a significant difference between chiral enantiomers at the optimal function time and the effect of the reaction.To our knowl-edge,this approach provides a new way to achieve important chiral discrimination for the pharmacokinetics and the phar-macodynamics and may present opportunities in indicating the health status of humans.

chiral detectionultrahigh-order guided modesmetal cladding optofluidic chiphigh sensitivitycircularly polarized light

魏麒恒、王雪茜、单洪瑞、来益、李鹤、戴海浪、陈险峰

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State Key Laboratory of Advanced Optical Communication Systems and Networks,School of Physics and Astronomy,Shanghai Jiao Tong University,Shanghai 200240,China

State Key Laboratory of Metal Matrix Composites,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

Department of Head and Neck Surgery and Department of Traditional Chinese Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China

Collaborative Innovation Center of Light Manipulations and Applications,Shandong Normal University,Jinan 250358,China

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National Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)Shanghai Municipal Science and Technology Major ProjectNatural Science Foundation of Shanghai

12104298121922522019SHZDZX01-0623ZR1428400

2024

10.3788/COL202422.081202

中国光学快报(英文版)
中国光学学会 中国科学院上海光学精密机械研究所

中国光学快报(英文版)

CSTPCD
影响因子：1.305
ISSN：1671-7694
年,卷(期)：2024.22(8)