首页|光动力疗法治疗宫颈上皮内瘤变的临床研究进展

光动力疗法治疗宫颈上皮内瘤变的临床研究进展

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宫颈癌在我国女性恶性肿瘤中为第六位高发性疾病,宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)是宫颈癌的癌前病变,由高危型人乳头瘤病毒(human papillomavirus,HPV)感染引起.随着CIN和宫颈癌的发病年龄高峰前移,育龄期患者人数增加,对于尚有生育需求的患者,发展一种能够保留宫颈结构功能的治疗方法具有重大临床意义.肿瘤靶向光动力疗法(photodynamic therapy,PDT)是一种安全、无创、靶向性好的治疗方法,能够在清除病灶和HPV感染的同时,保持宫颈结构和功能的完整性.目前PDT已在临床应用于CIN和HPV感染的治疗,本文对PDT治疗CIN的临床应用进展进行综述.
Advances in Clinical Research on Photodynamic Therapy for Treatment of Cervical Intraepithelial Neoplasia
Cervical cancer is the sixth most common malignant tumor among Chinese women,and cervical intraepithelial neoplasia(CIN)is a precancerous lesion of cervical cancer caused by high-risk human papilloma virus(HPV)infection.As the onset age peak of cervical intraepithelial neoplasia and cervical cancer moves forward,the number of patients of childbearing age increases.For patients with reproductive needs,it is of great clinical significance to develop a treatment that can retain the cervical structure and function.Tumor targeted photodynamic therapy(PDT)is a safe,non-invasive,and targeted therapy that can eliminate lesions and HPV infection while maintaining the structural and functional integrity of the cervix.At present,PDT has been applied clinically to the treatment of CIN and HPV infection.This paper reviews the progress of the clinical application of PDT in the treatment of CIN.

Photodynamic therapyCervical intraepithelial neoplasiaHuman papillomavirusCervical cancer

乔嘉璐、邱海霞、宁浩勇、朱晓明、谭一舟、顾瑛

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解放军医学院(北京市,100853)

中国人民解放军总医院第一医学中心激光医学科

中国人民解放军总医院海南医院病理科

中国人民解放军总医院海南医院妇产科

北京理工大学医学技术学院

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光动力疗法 宫颈上皮内瘤变 人乳头瘤病毒 宫颈癌

海南省重大科技计划海南省院士创新平台科研专项

ZDKJ2019012YSPTZX202202

2024

中国激光医学杂志
中国光学学会

中国激光医学杂志

CSTPCD
影响因子:0.677
ISSN:1003-9430
年,卷(期):2024.33(1)
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