首页|无创光疗调控真皮成纤维细胞在糖尿病足溃疡愈合的研究进展

无创光疗调控真皮成纤维细胞在糖尿病足溃疡愈合的研究进展

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糖尿病足(diabetic foot,DF)是糖尿病最严重的慢性并发症之一,糖尿病足溃疡(diabetic foot ulcers,DFUs)对糖尿病患者的截肢率和存活率有着直接影响.作为真皮最丰富的细胞,真皮成纤维细胞在糖尿病足溃疡的愈合过程中发挥着关键作用.目前对于糖尿病足溃疡缺乏特异有效的治疗方法,增加真皮成纤维细胞的功能促进溃疡愈合是一种有效的治疗策略.无创光疗(non-damage phototherapy,NDPT)作为一种无创、无毒副作用、非接触式的新辅助治疗方法,在糖尿病足溃疡的治疗中极具应用潜力.本文就糖尿病足溃疡中真皮成纤维细胞的异常改变及无创光疗通过调控真皮成纤维细胞治疗糖尿病足的基础和临床研究进展进行综述.
Research Progress of Non-Damage Phototherapy Regulating Dermal Fibroblasts in the Healing Process of Diabetic Foot Ulcer
Diabetes foot(DF)is one of the most serious chronic complications of diabetes.diabetes foot ulcers(DFUs)have a direct impact on the amputation rate and survival rate of diabetes patients.As the most abundant cells in the dermis,dermal fibroblasts play a key role in the healing process of DFUs.At present,there is no specific and effective treatment method for DFUs.Increasing the function of dermal fibroblasts to promote ulcer healing is an effective treatment strategy.Non-damage phototherapy(NDPT),as a non-invasive,non-toxic side effects and a non-contact new adjuvant treatment method,has great application potential in the treatment of DFUs.This article reviews the abnormal changes of dermal fibroblasts in DFUs,the basic and clinical research progress of NDPT in treating DFUs by regulating dermal fibroblasts.

Diabetes foot ulcersFibroblastsNon-damage phototherapyPhotobiomodulation

王子萱、冀全博、赵洪友、王颖、曾晶、顾瑛、邱海霞

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解放军医学院(北京市,100853)

中国人民解放军总医院第一医学中心激光医学科

中国人民解放军总医院第四医学中心骨科学部

北京理工大学医学技术学院

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糖尿病足溃疡 成纤维细胞 无创光疗 光生物调节

国家重点研发计划

2023YFB3609103

2024

中国激光医学杂志
中国光学学会

中国激光医学杂志

CSTPCD
影响因子:0.677
ISSN:1003-9430
年,卷(期):2024.33(3)