首页|全飞秒激光小切口角膜基质内透镜取出术治疗屈光不正的效果观察

全飞秒激光小切口角膜基质内透镜取出术治疗屈光不正的效果观察

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目的 观察飞秒激光制瓣的准分子激光原位角膜磨镶术(femtosecond laser-assisted laser in situ keratomileusis,FS-LASIK)和全飞秒激光小切口角膜基质内透镜取出术(small incision lenticule extraction,SMILE)治疗屈光不正的效果.方法 选择2020年5月至2022年5月,屈光不正患者85例169只眼,根据术式分为FS-LASIK组和SMILE组,其中FS-LASIK组患者42例83只眼,飞秒激光仪的激光波长1 053nm,能量130 nJ,准分子激光仪的激光波长193 nm,激光能量密度150 mJ/cm2;和SMILE组患者43例86只眼,飞秒激光仪的激光波长1 053nm,能量130 nJ.术后3、6、12个月,比较两组视力包括最佳矫正视力(best corrected visual acuity,BCVA)、裸眼视力(un-corrected visual acuity,UCVA)、屈光度包括球镜度(spherical,S)、柱镜度(cylinder,C)和等效球镜度(spherical equivalent,SE)、干眼检查包括眼泪膜破裂时间(tear break-up time,TBUT)、眼表疾病指数量表(ocular surface disease index,OSDI)评分和基础泪液分泌试验(Schirmer test,Sit),并比较两组术前和术后12个月的视觉敏感度.结果 术后3、6、12个月,两组UCVA与术前BCVA比较差异无统计学意义(P>0.05),且组间术后各时间UCVA比较、术后UCVA达到术前BCVA及超过术前BCVA的比例比较差异均无统计学意义(均P>0.05).两组术后3、6、12个月的S、C和SE均较术前降低,且组间术后各时间的S、C和SE比较差异均无统计学意义(均P>0.05),但SMILE组术后3~12个月的SE变化量明显低于FS-LASIK组(P<0.05).两组术后3个月的TBUT和Sit均较术前缩短/降低,但在术后6、12个月逐渐延长/升高,且SMILE组术后3、6、12个月的TBUT均长于/高于FS-LASIK组(均P<0.05),并在术后12个月基本恢复至术前水平(P>0.05);两组术后3个月的OSDI评分均较术前增加,但在术后6、12个月逐渐降低,且SMILE组术后3、6、12个月的OSDI评分均低于FS-LASIK组(均P<0.05),并在术后12个月基本恢复至术前水平(P>0.05).术后12个月,两组患者10%、25%、75%、100%对比度的视觉敏感度均增高,且SMILE组均高于FS-LASIK组(均P<0.05).结论 FS-LASIK和SMILE均可较好地改善患者视力和屈光不正状态,但SMILE在改善术后屈光度上拥有更长的稳定性,且对术后眼表的影响较小,术后干眼症状持续时间更短,恢复更快,同时可以改善患者的视觉敏感度,提高视觉质量.
Observation on Effect of Small Incision Lenticule Extraction on Refractive Errors
Objective To observe the effect of femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE)for the treatment of refractive errors.Methods The clinical data of 85 patients(169 eyes)with refractive errors admitted to our hospital between May 2020 and May 2022 were collected.The patients were divided into two groups by surgical methods:a FS-LASIK group(42 cases,83 eyes),for which the wavelength of the femtosecond laser used was 1 053 nm and energy 130 nJ,and the wavelength of the excimer laser used was 193 nm and energy density 150 mJ/cm2,and a SMILE group(43 cases,86 eyes),for which the wavelength of the femtosecond laser used was 1053nm and energy 130 nJ.The visual acuity[best corrected visual acuity(BCVA)and un-corrected visual acuity(UCVA)],refractive power[spherical(S),cylinder(C)and spherical equivalent(SE)],dry eye examination results[tear break-up time(TBUT),ocular surface disease index(OSDI)score and Schirmer test(SIt)]before and 3,6 and 12 months after the surgery were compared respectively.The visual sensitivity was also compared before and 12 months after the surgery respectively.Results For both groups,the UCVA was not different from the preoperative BCVA 3,6 and 12 months after the surgery(P>0.05).The difference between the two groups in UCVA and proportion of cases with UCVA reaching or exceeding preoperative BCVA to all cases was not great at any time point(P>0.05).For both groups,the S,C and SE were lower 3,6 and 12 months after the surgery than before the surgery,but the difference between the two groups in S,C and SE was not great at any time point(P>0.05).However,the SE changes in the SMILE group from 3 to 12 months after the surgery were much smaller than those in the FS-LASIK group(P<0.05).For both groups,the TBUT and Slt decreased 3 months after the operation,but increased gradually 6 and 12 months after the operation.Moreover,the TBUT in the SMILE group was longer/higher than those in the FS-LASIK group 3,6 and 12 months after the surgery(P<0.05),which basically returned to the preoperative levels 12 months after the operation.The OSDI scores in both groups increased 3 months after the operation,but gradually decreased 6 and 12 months after the operation.Moreover,the OSDI scores of the SMILE group were lower than those of the FS-LASIK group 3,6 and 12 months after the surgery(P<0.05),which basically returned to preoperative levels 12 months after the operation.For both groups,the visual sensitivity of 10%,25%,75%and 100%contrast was improved 12 months after the surgery,and the improvement was greater in the SMILE group than in the FS-LASIK group(P<0.05).Conclusions Both FS-LASIK and SMILE will effectively improve patients'vision and refractive error status,but SMILE features longer stability in improving postoperative refractive power,less impact on the postoperative eye surface and faster recovery thanks to shorter duration of dry eye symptoms caused by the surgery.Furthermore,SMILE will improve patients'visual sensitivity and visual quality.

Femtosecond laser-assisted laser in situ keratomileusisSmall incision lenticule extractionRefractive errorsBest corrected visual acuityDry eye

张语洋、王冬兰

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佳木斯爱尔眼科医院(佳木斯市,154000)

飞秒激光制瓣的准分子激光原位角膜磨镶术 全飞秒激光小切口角膜基质内透镜取出术 屈光不正 最佳矫正视力 干眼

2024

中国激光医学杂志
中国光学学会

中国激光医学杂志

CSTPCD
影响因子:0.677
ISSN:1003-9430
年,卷(期):2024.33(5)