Macrophages play an important role in fighting against glioblastoma(GBM).Photodynamic therapy(PDT)can be used to inhibit the development of glioblastoma by promoting the polarization of macrophages and explore the changes of tumor microenvironment(TME).In this paper,the literatures on photodynamic therapy for glioblas-toma in recent years are reviewed to study the role that PDT plays in the immune microenvironment of glioblastoma and the mechanism concerned.